Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-κB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt

Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme in the nicotinamide adenine dinucleotide (NAD(+)) biosynthetic pathway. Exogenous extra cellular Nampt has been reported to increase the synthesis of pro-fibrotic molecules in various types of renal cells. However, the role of endogenous...

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Detalles Bibliográficos
Autores principales: Chen, Ye, Liang, Yuzhen, Hu, Tingting, Wei, Riming, Cai, Congjie, Wang, Ping, Wang, Lingyu, Qiao, Wei, Feng, Leping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658765/
https://www.ncbi.nlm.nih.gov/pubmed/29104634
http://dx.doi.org/10.3892/etm.2017.5098

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