Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses

Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI...

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Autores principales: Raekiansyah, Muhareva, Mori, Mihoko, Nonaka, Kenichi, Agoh, Masanobu, Shiomi, Kazuro, Matsumoto, Atsuko, Morita, Kouichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658972/
https://www.ncbi.nlm.nih.gov/pubmed/29093640
http://dx.doi.org/10.1186/s41182-017-0072-7
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author Raekiansyah, Muhareva
Mori, Mihoko
Nonaka, Kenichi
Agoh, Masanobu
Shiomi, Kazuro
Matsumoto, Atsuko
Morita, Kouichi
author_facet Raekiansyah, Muhareva
Mori, Mihoko
Nonaka, Kenichi
Agoh, Masanobu
Shiomi, Kazuro
Matsumoto, Atsuko
Morita, Kouichi
author_sort Raekiansyah, Muhareva
collection PubMed
description Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery.
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spelling pubmed-56589722017-11-01 Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses Raekiansyah, Muhareva Mori, Mihoko Nonaka, Kenichi Agoh, Masanobu Shiomi, Kazuro Matsumoto, Atsuko Morita, Kouichi Trop Med Health Short Report Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain Penicillium sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery. BioMed Central 2017-10-26 /pmc/articles/PMC5658972/ /pubmed/29093640 http://dx.doi.org/10.1186/s41182-017-0072-7 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Raekiansyah, Muhareva
Mori, Mihoko
Nonaka, Kenichi
Agoh, Masanobu
Shiomi, Kazuro
Matsumoto, Atsuko
Morita, Kouichi
Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title_full Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title_fullStr Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title_full_unstemmed Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title_short Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses
title_sort identification of novel antiviral of fungus-derived brefeldin a against dengue viruses
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658972/
https://www.ncbi.nlm.nih.gov/pubmed/29093640
http://dx.doi.org/10.1186/s41182-017-0072-7
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