Controlling the activity of quorum sensing autoinducers with light

Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employin...

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Detalles Bibliográficos
Autores principales: Van der Berg, J. P., Velema, W. A., Szymanski, W., Driessen, A. J. M., Feringa, B. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659144/
https://www.ncbi.nlm.nih.gov/pubmed/29511521
http://dx.doi.org/10.1039/c5sc00215j
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author Van der Berg, J. P.
Velema, W. A.
Szymanski, W.
Driessen, A. J. M.
Feringa, B. L.
author_facet Van der Berg, J. P.
Velema, W. A.
Szymanski, W.
Driessen, A. J. M.
Feringa, B. L.
author_sort Van der Berg, J. P.
collection PubMed
description Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.
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spelling pubmed-56591442018-03-06 Controlling the activity of quorum sensing autoinducers with light Van der Berg, J. P. Velema, W. A. Szymanski, W. Driessen, A. J. M. Feringa, B. L. Chem Sci Chemistry Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa. Royal Society of Chemistry 2015-06-01 2015-04-27 /pmc/articles/PMC5659144/ /pubmed/29511521 http://dx.doi.org/10.1039/c5sc00215j Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Van der Berg, J. P.
Velema, W. A.
Szymanski, W.
Driessen, A. J. M.
Feringa, B. L.
Controlling the activity of quorum sensing autoinducers with light
title Controlling the activity of quorum sensing autoinducers with light
title_full Controlling the activity of quorum sensing autoinducers with light
title_fullStr Controlling the activity of quorum sensing autoinducers with light
title_full_unstemmed Controlling the activity of quorum sensing autoinducers with light
title_short Controlling the activity of quorum sensing autoinducers with light
title_sort controlling the activity of quorum sensing autoinducers with light
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659144/
https://www.ncbi.nlm.nih.gov/pubmed/29511521
http://dx.doi.org/10.1039/c5sc00215j
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