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Developing a novel dual PI3K–mTOR inhibitor from the prodrug of a metabolite

This study presents a process of developing a novel PI3K–mTOR inhibitor through the prodrug of a metabolite. The lead compound (compound 1) was identified with similar efficacy as that of NVP-BEZ235 in a tumor xenograft model, but the exposure of compound 1 was much lower than that of NVP-BEZ235. Af...

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Detalles Bibliográficos
Autores principales:	Zhou, Yan, Zhang, Genyan, Wang, Feng, Wang, Jin, Ding, Yanwei, Li, Xinyu, Shi, Chongtie, Li, Jiakui, Shih, Chengkon, You, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659256/ https://www.ncbi.nlm.nih.gov/pubmed/29118584 http://dx.doi.org/10.2147/OTT.S142492

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