Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

PURPOSE: Methotrexate is widely used in chemotherapy for a variety of malignancies. However, severe toxicity, poor pharmacokinetics, and narrow safety margin of methotrexate limit its clinical application. The aim of this study was to develop sustained-release methotrexate-loaded implants and evalua...

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Detalles Bibliográficos
Autores principales: Gao, Li, Xia, Lunyang, Zhang, Ruhui, Duan, Dandan, Liu, Xiuxiu, Xu, Jianjian, Luo, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659257/
https://www.ncbi.nlm.nih.gov/pubmed/29118572
http://dx.doi.org/10.2147/DDDT.S143942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659257/
https://www.ncbi.nlm.nih.gov/pubmed/29118572
http://dx.doi.org/10.2147/DDDT.S143942

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