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Enhanced antitumor efficacy of poly(D,L-lactide-co-glycolide)-based methotrexate-loaded implants on sarcoma 180 tumor-bearing mice

PURPOSE: Methotrexate is widely used in chemotherapy for a variety of malignancies. However, severe toxicity, poor pharmacokinetics, and narrow safety margin of methotrexate limit its clinical application. The aim of this study was to develop sustained-release methotrexate-loaded implants and evalua...

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Detalles Bibliográficos
Autores principales:	Gao, Li, Xia, Lunyang, Zhang, Ruhui, Duan, Dandan, Liu, Xiuxiu, Xu, Jianjian, Luo, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659257/ https://www.ncbi.nlm.nih.gov/pubmed/29118572 http://dx.doi.org/10.2147/DDDT.S143942

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