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Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model

A fully synthetic electrospun matrix was compared to a bi-layered xenograft in the healing of full thickness cutaneous wounds in Yucatan miniature swine. Full thickness wounds were created along the dorsum, to which these matrices were applied. The wound area was measured over the course of healing...

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Autores principales: MacEwan, Matthew R, MacEwan, Sarah, Wright, Anna P, Kovacs, Tamas R, Batts, Joel, Zhang, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659317/
https://www.ncbi.nlm.nih.gov/pubmed/29098126
http://dx.doi.org/10.7759/cureus.1614
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author MacEwan, Matthew R
MacEwan, Sarah
Wright, Anna P
Kovacs, Tamas R
Batts, Joel
Zhang, Luke
author_facet MacEwan, Matthew R
MacEwan, Sarah
Wright, Anna P
Kovacs, Tamas R
Batts, Joel
Zhang, Luke
author_sort MacEwan, Matthew R
collection PubMed
description A fully synthetic electrospun matrix was compared to a bi-layered xenograft in the healing of full thickness cutaneous wounds in Yucatan miniature swine. Full thickness wounds were created along the dorsum, to which these matrices were applied. The wound area was measured over the course of healing and wound tissue was scored for evidence of inflammation and healing. Animals were sacrificed at Day 15 and Day 30 and tissue samples from the wound site were harvested for histopathological analysis to evaluate inflammation and tissue healing as evidenced by granulation tissue, collagen maturation, vascularization, and epithelialization. Average wound area was significantly smaller for treatment group wounds compared to control group wounds at 15 and 30 days ([7.7 cm(2 )± 0.9]/[3.8 cm(2 )± 0.8]) and ([2.9 cm(2 )± 1.1]/[0.2 cm(2 )± 0.0]) (control/treatment) (p = 0.002/p = 0.01). Histopathological analysis of wound sections revealed superior quality of healing with treatment group wounds, as measured by inflammatory response, granulation tissue, and re-epithelialization. A fully synthetic electrospun matrix was associated with faster rates of wound closure characterized by granulation tissue, deposition of mature collagen and vascularization at earlier time points than in wounds treated with a bi-layered xenograft. Treatment with this fully synthetic material may represent a new standard of care by facilitating full-thickness wound closure while eliminating the risks of inflammatory response and disease transmission associated with biologic modalities.
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spelling pubmed-56593172017-11-02 Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model MacEwan, Matthew R MacEwan, Sarah Wright, Anna P Kovacs, Tamas R Batts, Joel Zhang, Luke Cureus Healthcare Technology A fully synthetic electrospun matrix was compared to a bi-layered xenograft in the healing of full thickness cutaneous wounds in Yucatan miniature swine. Full thickness wounds were created along the dorsum, to which these matrices were applied. The wound area was measured over the course of healing and wound tissue was scored for evidence of inflammation and healing. Animals were sacrificed at Day 15 and Day 30 and tissue samples from the wound site were harvested for histopathological analysis to evaluate inflammation and tissue healing as evidenced by granulation tissue, collagen maturation, vascularization, and epithelialization. Average wound area was significantly smaller for treatment group wounds compared to control group wounds at 15 and 30 days ([7.7 cm(2 )± 0.9]/[3.8 cm(2 )± 0.8]) and ([2.9 cm(2 )± 1.1]/[0.2 cm(2 )± 0.0]) (control/treatment) (p = 0.002/p = 0.01). Histopathological analysis of wound sections revealed superior quality of healing with treatment group wounds, as measured by inflammatory response, granulation tissue, and re-epithelialization. A fully synthetic electrospun matrix was associated with faster rates of wound closure characterized by granulation tissue, deposition of mature collagen and vascularization at earlier time points than in wounds treated with a bi-layered xenograft. Treatment with this fully synthetic material may represent a new standard of care by facilitating full-thickness wound closure while eliminating the risks of inflammatory response and disease transmission associated with biologic modalities. Cureus 2017-08-27 /pmc/articles/PMC5659317/ /pubmed/29098126 http://dx.doi.org/10.7759/cureus.1614 Text en Copyright © 2017, MacEwan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Healthcare Technology
MacEwan, Matthew R
MacEwan, Sarah
Wright, Anna P
Kovacs, Tamas R
Batts, Joel
Zhang, Luke
Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title_full Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title_fullStr Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title_full_unstemmed Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title_short Comparison of a Fully Synthetic Electrospun Matrix to a Bi-Layered Xenograft in Healing Full Thickness Cutaneous Wounds in a Porcine Model
title_sort comparison of a fully synthetic electrospun matrix to a bi-layered xenograft in healing full thickness cutaneous wounds in a porcine model
topic Healthcare Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659317/
https://www.ncbi.nlm.nih.gov/pubmed/29098126
http://dx.doi.org/10.7759/cureus.1614
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