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The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total...

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Autores principales: Lee, Hye Won, Kim, Kwang Joon, Jung, Kyu Sik, Chon, Young Eun, Huh, Ji Hye, Park, Kyeong Hye, Chung, Jae Bock, Kim, Chang Oh, Han, Kwang-Hyub, Park, Jun Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659780/
https://www.ncbi.nlm.nih.gov/pubmed/29077769
http://dx.doi.org/10.1371/journal.pone.0187066
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author Lee, Hye Won
Kim, Kwang Joon
Jung, Kyu Sik
Chon, Young Eun
Huh, Ji Hye
Park, Kyeong Hye
Chung, Jae Bock
Kim, Chang Oh
Han, Kwang-Hyub
Park, Jun Yong
author_facet Lee, Hye Won
Kim, Kwang Joon
Jung, Kyu Sik
Chon, Young Eun
Huh, Ji Hye
Park, Kyeong Hye
Chung, Jae Bock
Kim, Chang Oh
Han, Kwang-Hyub
Park, Jun Yong
author_sort Lee, Hye Won
collection PubMed
description BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. RESULTS: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm(2) and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm(2), compared to patients with a VFA ≤100 cm(2). CONCLUSIONS: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI.
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spelling pubmed-56597802017-11-09 The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter Lee, Hye Won Kim, Kwang Joon Jung, Kyu Sik Chon, Young Eun Huh, Ji Hye Park, Kyeong Hye Chung, Jae Bock Kim, Chang Oh Han, Kwang-Hyub Park, Jun Yong PLoS One Research Article BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely related with obesity. However, obese subjects, generally represented by high BMI, do not always develop NAFLD. A number of possible causes of NAFLD have been studied, but the exact mechanism has not yet been elucidated. METHODS: A total of 304 consecutive subjects who underwent general health examinations including abdominal ultrasonography, transient elastography and abdominal fat computed tomography were prospectively enrolled. Significant steatosis was diagnosed by ultrasonography and controlled attenuation parameter (CAP) assessed by transient elastography. RESULTS: Visceral fat area (VFA) was significantly related to hepatic steatosis assessed by CAP, whereas body mass index (BMI) was related to CAP only in univariate analysis. In multiple logistic regression analysis, VFA (odds ratio [OR], 1.010; 95% confidence interval [CI], 1.001–1.019; P = 0.028) and triglycerides (TG) (OR, 1.006; 95% CI, 1.001–1.011; P = 0.022) were independent risk factors for significant hepatic steatosis. The risk of significant hepatic steatosis was higher in patients with higher VFA: the OR was 4.838 (P<0.001; 95% CI, 2.912–8.039) for 100<VFA≤200 cm(2) and 7.474 (P<0.001; 95% CI, 2.462–22.693) for VFA >200 cm(2), compared to patients with a VFA ≤100 cm(2). CONCLUSIONS: Our data demonstrated that VFA and TG is significantly related to hepatic steatosis assessed by CAP not BMI. This finding suggests that surveillance for subjects with NAFLD should incorporate an indicator of visceral obesity, and not simply rely on BMI. Public Library of Science 2017-10-27 /pmc/articles/PMC5659780/ /pubmed/29077769 http://dx.doi.org/10.1371/journal.pone.0187066 Text en © 2017 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Hye Won
Kim, Kwang Joon
Jung, Kyu Sik
Chon, Young Eun
Huh, Ji Hye
Park, Kyeong Hye
Chung, Jae Bock
Kim, Chang Oh
Han, Kwang-Hyub
Park, Jun Yong
The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title_full The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title_fullStr The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title_full_unstemmed The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title_short The relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
title_sort relationship between visceral obesity and hepatic steatosis measured by controlled attenuation parameter
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659780/
https://www.ncbi.nlm.nih.gov/pubmed/29077769
http://dx.doi.org/10.1371/journal.pone.0187066
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