Patient-derived xenografts undergo murine-specific tumor evolution

Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they are presumed to faithfully represent the genomic features of primary tumors. Here we monitored the dynamics of copy number alterations (CNAs) in 1,110 PDX samples across 24 cancer types. We observed rapid accumula...

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Detalles Bibliográficos
Autores principales: Ben-David, Uri, Ha, Gavin, Tseng, Yuen-Yi, Greenwald, Noah F., Oh, Coyin, Shih, Juliann, McFarland, James M., Wong, Bang, Boehm, Jesse S., Beroukhim, Rameen, Golub, Todd R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659952/
https://www.ncbi.nlm.nih.gov/pubmed/28991255
http://dx.doi.org/10.1038/ng.3967

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