A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Astrocyte responses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanisms that determine these different responses are poorly understood. Here we show that ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astr...

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Detalles Bibliográficos
Autores principales: Tyzack, Giulia E., Hall, Claire E., Sibley, Christopher R., Cymes, Tomasz, Forostyak, Serhiy, Carlino, Giulia, Meyer, Ione F., Schiavo, Giampietro, Zhang, Su-Chun, Gibbons, George M., Newcombe, Jia, Patani, Rickie, Lakatos, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660125/
https://www.ncbi.nlm.nih.gov/pubmed/29079839
http://dx.doi.org/10.1038/s41467-017-01283-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660125/
https://www.ncbi.nlm.nih.gov/pubmed/29079839
http://dx.doi.org/10.1038/s41467-017-01283-z

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