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The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation
The biosynthesis of the major acyl carrier Coenzyme A from pantothenic acid (PA) is critical for survival of Plasmodium falciparum within human erythrocytes. Accordingly, a PA analog α-PanAm showed potent activity against blood stage parasites in vitro; however, its efficacy in vivo and its mode of...
Autores principales: | Chiu, Joy E., Thekkiniath, Jose, Choi, Jae-Yeon, Perrin, Benjamin A., Lawres, Lauren, Plummer, Mark, Virji, Azan Z., Abraham, Amanah, Toh, Justin Y., Zandt, Michael Van, Aly, Ahmed S. I., Voelker, Dennis R., Mamoun, Choukri Ben |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660193/ https://www.ncbi.nlm.nih.gov/pubmed/29079738 http://dx.doi.org/10.1038/s41598-017-14074-9 |
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