Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1(+/−) granule cell precursors after radiation injury

Medulloblastoma (MB) is the most common pediatric brain tumor, comprising four distinct molecular variants, one of which characterized by activation of the Sonic Hedgehog (SHH) pathway, driving 25–30% of sporadic MB. SHH-dependent MBs arise from granule cell precursors (GCPs), are fatal in 40–70% of...

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Detalles Bibliográficos
Autores principales: Tanno, Barbara, Leonardi, Simona, Babini, Gabriele, Giardullo, Paola, De Stefano, Ilaria, Pasquali, Emanuela, Saran, Anna, Mancuso, Mariateresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660207/
https://www.ncbi.nlm.nih.gov/pubmed/29079783
http://dx.doi.org/10.1038/s41598-017-14506-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660207/
https://www.ncbi.nlm.nih.gov/pubmed/29079783
http://dx.doi.org/10.1038/s41598-017-14506-6

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