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Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1(+/−) granule cell precursors after radiation injury
Medulloblastoma (MB) is the most common pediatric brain tumor, comprising four distinct molecular variants, one of which characterized by activation of the Sonic Hedgehog (SHH) pathway, driving 25–30% of sporadic MB. SHH-dependent MBs arise from granule cell precursors (GCPs), are fatal in 40–70% of...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660207/ https://www.ncbi.nlm.nih.gov/pubmed/29079783 http://dx.doi.org/10.1038/s41598-017-14506-6 |