Margination and stretching of von Willebrand factor in the blood stream enable adhesion

The protein von Willebrand factor (VWF) is essential in primary hemostasis, as it mediates platelet adhesion to vessel walls. VWF retains its compact (globule-like) shape in equilibrium due to internal molecular associations, but is able to stretch when a high enough shear stress is applied. Even th...

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Detalles Bibliográficos
Autores principales: Rack, Kathrin, Huck, Volker, Hoore, Masoud, Fedosov, Dmitry A., Schneider, Stefan W., Gompper, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660260/
https://www.ncbi.nlm.nih.gov/pubmed/29079767
http://dx.doi.org/10.1038/s41598-017-14346-4

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