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Results of liver transplantation with donors older than 80 years: a case control study
AIM: The inclusion of elderly donors can increase the pool of organs available for transplant. BACKGROUND: To compare clinical outcomes and survival rates in patients who received livers from donors aged ≥ 80 years vs. younger donors. METHODS: We considered all liver transplantations performed in ou...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660266/ https://www.ncbi.nlm.nih.gov/pubmed/29118932 |
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author | Díaz, Francisco Javier León Aguilar, José Luis Fernández Pérez, Belinda Sánchez Casado, Custodia Montiel Narváez, José Manuel Aranda Daga, José Antonio Pérez Muñoz, Miguel Ángel Suárez Santoyo, Julio Santoyo |
author_facet | Díaz, Francisco Javier León Aguilar, José Luis Fernández Pérez, Belinda Sánchez Casado, Custodia Montiel Narváez, José Manuel Aranda Daga, José Antonio Pérez Muñoz, Miguel Ángel Suárez Santoyo, Julio Santoyo |
author_sort | Díaz, Francisco Javier León |
collection | PubMed |
description | AIM: The inclusion of elderly donors can increase the pool of organs available for transplant. BACKGROUND: To compare clinical outcomes and survival rates in patients who received livers from donors aged ≥ 80 years vs. younger donors. METHODS: We considered all liver transplantations performed in our unit between January 2006 and January 2015. Twelve patients received liver from a cadaveric donor aged ≥ 80 years (study group) and their outcomes were compared with those of patients who received liver from a younger donor (control group). This study was carried out to analyze the characteristics of donors and recipients, as well as the clinical course and survival of recipients. RESULTS: Statistically significant differences were observed in donors' age (55.6 ± 14.4 vs. 82.7 ± 2.7 years, p < 0.001), donors' ICU stay (p = 0.008), donors' ALT levels (p = 0.009) and donors' AST levels (p = 0.01). Statistically significant differences were found in ischemia time (p < 0.05). In total, 8.3% of the recipients of liver from a donor aged < 80 required retransplantation vs. 25% of recipients of donor’s ≥ 80 years. Patient survival at one, three and five years was 89%, 78.6% and 74.5%, respectively vs. 83.4%, 79.4% and 59.6% for the study group. CONCLUSION: Livers from older donors can be safely used for transplantation with acceptable patient survival rates. However, graft survival rates are lower for recipients of livers from older donors as compared to younger donors, and survival only increased with retransplantation. |
format | Online Article Text |
id | pubmed-5660266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-56602662017-11-08 Results of liver transplantation with donors older than 80 years: a case control study Díaz, Francisco Javier León Aguilar, José Luis Fernández Pérez, Belinda Sánchez Casado, Custodia Montiel Narváez, José Manuel Aranda Daga, José Antonio Pérez Muñoz, Miguel Ángel Suárez Santoyo, Julio Santoyo Gastroenterol Hepatol Bed Bench Original Article AIM: The inclusion of elderly donors can increase the pool of organs available for transplant. BACKGROUND: To compare clinical outcomes and survival rates in patients who received livers from donors aged ≥ 80 years vs. younger donors. METHODS: We considered all liver transplantations performed in our unit between January 2006 and January 2015. Twelve patients received liver from a cadaveric donor aged ≥ 80 years (study group) and their outcomes were compared with those of patients who received liver from a younger donor (control group). This study was carried out to analyze the characteristics of donors and recipients, as well as the clinical course and survival of recipients. RESULTS: Statistically significant differences were observed in donors' age (55.6 ± 14.4 vs. 82.7 ± 2.7 years, p < 0.001), donors' ICU stay (p = 0.008), donors' ALT levels (p = 0.009) and donors' AST levels (p = 0.01). Statistically significant differences were found in ischemia time (p < 0.05). In total, 8.3% of the recipients of liver from a donor aged < 80 required retransplantation vs. 25% of recipients of donor’s ≥ 80 years. Patient survival at one, three and five years was 89%, 78.6% and 74.5%, respectively vs. 83.4%, 79.4% and 59.6% for the study group. CONCLUSION: Livers from older donors can be safely used for transplantation with acceptable patient survival rates. However, graft survival rates are lower for recipients of livers from older donors as compared to younger donors, and survival only increased with retransplantation. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5660266/ /pubmed/29118932 Text en ©2017 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Díaz, Francisco Javier León Aguilar, José Luis Fernández Pérez, Belinda Sánchez Casado, Custodia Montiel Narváez, José Manuel Aranda Daga, José Antonio Pérez Muñoz, Miguel Ángel Suárez Santoyo, Julio Santoyo Results of liver transplantation with donors older than 80 years: a case control study |
title | Results of liver transplantation with donors older than 80 years: a case control study |
title_full | Results of liver transplantation with donors older than 80 years: a case control study |
title_fullStr | Results of liver transplantation with donors older than 80 years: a case control study |
title_full_unstemmed | Results of liver transplantation with donors older than 80 years: a case control study |
title_short | Results of liver transplantation with donors older than 80 years: a case control study |
title_sort | results of liver transplantation with donors older than 80 years: a case control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660266/ https://www.ncbi.nlm.nih.gov/pubmed/29118932 |
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