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Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients
AIM: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients. BACKGROUND: Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660267/ https://www.ncbi.nlm.nih.gov/pubmed/29118933 |
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author | Shavalipour, Aref Malekpour, Habib Dabiri, Hossein Kazemian, Hossein Zojaji, Homayon Bahroudi, Mahboube |
author_facet | Shavalipour, Aref Malekpour, Habib Dabiri, Hossein Kazemian, Hossein Zojaji, Homayon Bahroudi, Mahboube |
author_sort | Shavalipour, Aref |
collection | PubMed |
description | AIM: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients. BACKGROUND: Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH causes tissue damage. Helicobacter pylori may or may not influence the GERD; however, it is unclear. METHODS: This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran. Prevalence of H. pylori and presence of the cag A and cag E genes in GERD and control group was investigated. RESULTS: H. pylori was detected in 54% and 62% of GERD and control groups respectively. Prevalence of cag A gene among GERD patients was 44.4% whereas among the control group it was 87%. Prevalence of the cag E among GERD patients and control group was 44.4% and 64% respectively. Coexistence of cag A and cag E in GERD patients was 25.7% and in the control patients it was 54.8%. CONCLUSION: We did not find correlation between H. pylori existence in GERD patients in comparison to the control group. Similar to other Asian studies, the presence of the cag A in control group was more than GERD patients significantly. The co-existence of cag A and cag E was also more in control group significantly. |
format | Online Article Text |
id | pubmed-5660267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-56602672017-11-08 Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients Shavalipour, Aref Malekpour, Habib Dabiri, Hossein Kazemian, Hossein Zojaji, Homayon Bahroudi, Mahboube Gastroenterol Hepatol Bed Bench Original Article AIM: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients. BACKGROUND: Gastroesophageal reflux disease (GERD) is defined as a condition of reflux the stomach juice by low pH causes tissue damage. Helicobacter pylori may or may not influence the GERD; however, it is unclear. METHODS: This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran. Prevalence of H. pylori and presence of the cag A and cag E genes in GERD and control group was investigated. RESULTS: H. pylori was detected in 54% and 62% of GERD and control groups respectively. Prevalence of cag A gene among GERD patients was 44.4% whereas among the control group it was 87%. Prevalence of the cag E among GERD patients and control group was 44.4% and 64% respectively. Coexistence of cag A and cag E in GERD patients was 25.7% and in the control patients it was 54.8%. CONCLUSION: We did not find correlation between H. pylori existence in GERD patients in comparison to the control group. Similar to other Asian studies, the presence of the cag A in control group was more than GERD patients significantly. The co-existence of cag A and cag E was also more in control group significantly. Shaheed Beheshti University of Medical Sciences 2017 /pmc/articles/PMC5660267/ /pubmed/29118933 Text en ©2017 RIGLD, Research Institute for Gastroenterology and Liver Diseases This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shavalipour, Aref Malekpour, Habib Dabiri, Hossein Kazemian, Hossein Zojaji, Homayon Bahroudi, Mahboube Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title | Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title_full | Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title_fullStr | Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title_full_unstemmed | Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title_short | Prevalence of cytotoxin-associated genes of Helicobacter pylori among Iranian GERD patients |
title_sort | prevalence of cytotoxin-associated genes of helicobacter pylori among iranian gerd patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660267/ https://www.ncbi.nlm.nih.gov/pubmed/29118933 |
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