CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2(N141I) neurons

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval. We present an optimized in vitro protocol to generate human BFCNs from...

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Detalles Bibliográficos
Autores principales: Ortiz-Virumbrales, Maitane, Moreno, Cesar L., Kruglikov, Ilya, Marazuela, Paula, Sproul, Andrew, Jacob, Samson, Zimmer, Matthew, Paull, Daniel, Zhang, Bin, Schadt, Eric E., Ehrlich, Michelle E., Tanzi, Rudolph E., Arancio, Ottavio, Noggle, Scott, Gandy, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660456/
https://www.ncbi.nlm.nih.gov/pubmed/29078805
http://dx.doi.org/10.1186/s40478-017-0475-z

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