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A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning

OBJECTIVES: Clinical studies to reduce the side effects of tramadol, such as seizure, are necessary. Owing to the high prevalence of tramadol consumption and subsequent complications that result from seizures, the aim of the present study was to find a relationship between clonus and prediction of s...

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Autores principales: Najari, Fares, Alizadeh-Ghamsari, Anahita, Vahabzadeh, Maryam, Dadpour, Bita, Reza Mousavi, Seyed, Baradaran Kayal, Ideh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660783/
https://www.ncbi.nlm.nih.gov/pubmed/29158734
http://dx.doi.org/10.1155/2017/2151536
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author Najari, Fares
Alizadeh-Ghamsari, Anahita
Vahabzadeh, Maryam
Dadpour, Bita
Reza Mousavi, Seyed
Baradaran Kayal, Ideh
author_facet Najari, Fares
Alizadeh-Ghamsari, Anahita
Vahabzadeh, Maryam
Dadpour, Bita
Reza Mousavi, Seyed
Baradaran Kayal, Ideh
author_sort Najari, Fares
collection PubMed
description OBJECTIVES: Clinical studies to reduce the side effects of tramadol, such as seizure, are necessary. Owing to the high prevalence of tramadol consumption and subsequent complications that result from seizures, the aim of the present study was to find a relationship between clonus and prediction of seizure outcome in patients with tramadol overdose. This can be used to determine the need for essential actions if a significant indicator of preventive medical measures is observed. METHODS: In this case-control study, three groups of patients poisoned with tramadol and with marked ankle clonus were evaluated. A sample size of 50 patients per group was calculated using the Cohen first method. The data were analyzed using SPSS16 software. RESULTS: All patients with ankle clonus were evaluated. Seizures occurred most commonly in patients aged 21–25 years or younger. The patients who received the preventive medication of magnesium sulfate were seizure-free for 72 h after admission. CONCLUSION: It is recommended that, for all patients referred with tramadol poisoning who have symptoms of ankle clonus, the administration of magnesium sulfate should be considered in addition to medication for the prevention of seizures and arrhythmias.
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spelling pubmed-56607832017-11-20 A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning Najari, Fares Alizadeh-Ghamsari, Anahita Vahabzadeh, Maryam Dadpour, Bita Reza Mousavi, Seyed Baradaran Kayal, Ideh J Toxicol Research Article OBJECTIVES: Clinical studies to reduce the side effects of tramadol, such as seizure, are necessary. Owing to the high prevalence of tramadol consumption and subsequent complications that result from seizures, the aim of the present study was to find a relationship between clonus and prediction of seizure outcome in patients with tramadol overdose. This can be used to determine the need for essential actions if a significant indicator of preventive medical measures is observed. METHODS: In this case-control study, three groups of patients poisoned with tramadol and with marked ankle clonus were evaluated. A sample size of 50 patients per group was calculated using the Cohen first method. The data were analyzed using SPSS16 software. RESULTS: All patients with ankle clonus were evaluated. Seizures occurred most commonly in patients aged 21–25 years or younger. The patients who received the preventive medication of magnesium sulfate were seizure-free for 72 h after admission. CONCLUSION: It is recommended that, for all patients referred with tramadol poisoning who have symptoms of ankle clonus, the administration of magnesium sulfate should be considered in addition to medication for the prevention of seizures and arrhythmias. Hindawi 2017 2017-10-11 /pmc/articles/PMC5660783/ /pubmed/29158734 http://dx.doi.org/10.1155/2017/2151536 Text en Copyright © 2017 Fares Najari et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Najari, Fares
Alizadeh-Ghamsari, Anahita
Vahabzadeh, Maryam
Dadpour, Bita
Reza Mousavi, Seyed
Baradaran Kayal, Ideh
A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title_full A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title_fullStr A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title_full_unstemmed A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title_short A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning
title_sort study of the importance of clonus symptoms in patients with tramadol poisoning
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660783/
https://www.ncbi.nlm.nih.gov/pubmed/29158734
http://dx.doi.org/10.1155/2017/2151536
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