Phenotypic Screen Identifies a Small Molecule Modulating ERK2 and Promoting Stem Cell Proliferation

Stem cells display a fundamentally different mechanism of proliferation control when compared to somatic cells. Uncovering these mechanisms would maximize the impact in drug discovery with a higher translational applicability. The unbiased approach used in phenotype-based drug discovery (PDD) progra...

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Detalles Bibliográficos
Autores principales: Yin, Chang, Fufa, Temesgen, Chandrasekar, Gayathri, Aeluri, Madhu, Zaky, Verina, Abdelhady, Shaimaa, Rodríguez, Antonio B., Jakobsson, Johan, Varnoosfaderani, Farzaneh Shahin, Mahalingam, Jayashri, Liu, Jianping, Larsson, Olle, Hovatta, Outi, Gaunitz, Frank, Göndör, Anita, Andäng, Michael, Kitambi, Satish S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660848/
https://www.ncbi.nlm.nih.gov/pubmed/29114221
http://dx.doi.org/10.3389/fphar.2017.00726

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