Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis

Recent discovery of hair follicle keratin 75 (KRT75) in enamel raises questions about the function of this protein in enamel and the mechanisms of its secretion. It is also not clear how this protein with a very specific and narrow expression pattern, limited to the inner root sheath of the hair fol...

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Autor principal: Beniash, Elia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660855/
https://www.ncbi.nlm.nih.gov/pubmed/29114231
http://dx.doi.org/10.3389/fphys.2017.00823
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author Beniash, Elia
author_facet Beniash, Elia
author_sort Beniash, Elia
collection PubMed
description Recent discovery of hair follicle keratin 75 (KRT75) in enamel raises questions about the function of this protein in enamel and the mechanisms of its secretion. It is also not clear how this protein with a very specific and narrow expression pattern, limited to the inner root sheath of the hair follicle, became associated with enamel. We propose a hypothesis that KRT75 was co-opted by ameloblasts during the evolution of Tomes' process and the prismatic enamel in synapsids.
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spelling pubmed-56608552017-11-07 Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis Beniash, Elia Front Physiol Physiology Recent discovery of hair follicle keratin 75 (KRT75) in enamel raises questions about the function of this protein in enamel and the mechanisms of its secretion. It is also not clear how this protein with a very specific and narrow expression pattern, limited to the inner root sheath of the hair follicle, became associated with enamel. We propose a hypothesis that KRT75 was co-opted by ameloblasts during the evolution of Tomes' process and the prismatic enamel in synapsids. Frontiers Media S.A. 2017-10-24 /pmc/articles/PMC5660855/ /pubmed/29114231 http://dx.doi.org/10.3389/fphys.2017.00823 Text en Copyright © 2017 Beniash. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Beniash, Elia
Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title_full Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title_fullStr Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title_full_unstemmed Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title_short Co-option of Hair Follicle Keratins into Amelogenesis Is Associated with the Evolution of Prismatic Enamel: A Hypothesis
title_sort co-option of hair follicle keratins into amelogenesis is associated with the evolution of prismatic enamel: a hypothesis
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660855/
https://www.ncbi.nlm.nih.gov/pubmed/29114231
http://dx.doi.org/10.3389/fphys.2017.00823
work_keys_str_mv AT beniashelia cooptionofhairfolliclekeratinsintoamelogenesisisassociatedwiththeevolutionofprismaticenamelahypothesis

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