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Excess cholesterol inhibits glucose‐stimulated fusion pore dynamics in insulin exocytosis

Type 2 diabetes is caused by defects in both insulin sensitivity and insulin secretion. Glucose triggers insulin secretion by causing exocytosis of insulin granules from pancreatic β‐cells. High circulating cholesterol levels and a diminished capacity of serum to remove cholesterol from β‐cells are...

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Detalles Bibliográficos
Autores principales:	Xu, Yingke, Toomre, Derek K., Bogan, Jonathan S., Hao, Mingming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661106/ https://www.ncbi.nlm.nih.gov/pubmed/28544529 http://dx.doi.org/10.1111/jcmm.13207

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