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Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans
Inhibitory propriospinal neurons with diffuse projections onto upper limb motoneurons have been revealed in humans using peripheral nerve stimulation. This system is supposed to mediate descending inhibition to motoneurons, to prevent unwilling muscle activity. However, the corticospinal control ont...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661226/ https://www.ncbi.nlm.nih.gov/pubmed/29084839 http://dx.doi.org/10.14814/phy2.13387 |
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author | Giboin, Louis‐Solal Sangari, Sina Lackmy‐Vallée, Alexandra Messé, Arnaud Pradat‐Diehl, Pascale Marchand‐Pauvert, Véronique |
author_facet | Giboin, Louis‐Solal Sangari, Sina Lackmy‐Vallée, Alexandra Messé, Arnaud Pradat‐Diehl, Pascale Marchand‐Pauvert, Véronique |
author_sort | Giboin, Louis‐Solal |
collection | PubMed |
description | Inhibitory propriospinal neurons with diffuse projections onto upper limb motoneurons have been revealed in humans using peripheral nerve stimulation. This system is supposed to mediate descending inhibition to motoneurons, to prevent unwilling muscle activity. However, the corticospinal control onto inhibitory propriospinal neurons has never been investigated so far in humans. We addressed the question whether inhibitory cervical propriospinal neurons receive corticospinal inputs from primary motor (M1) and ventral premotor areas (PMv) using spatial facilitation method. We have stimulated M1 or PMv using transcranial magnetic stimulation (TMS) and/or median nerve whose afferents are known to activate inhibitory propriospinal neurons. Potential input convergence was evaluated by studying the change in monosynaptic reflexes produced in wrist extensor electromyogram (EMG) after isolated and combined stimuli in 17 healthy subjects. Then, to determine whether PMv controlled propriospinal neurons directly or through PMv‐M1 interaction, we tested the connectivity between PMv and propriospinal neurons after a functional disruption of M1 produced by paired continuous theta burst stimulation (cTBS). TMS over M1 or PMv produced reflex inhibition significantly stronger on combined stimulations, compared to the algebraic sum of effects induced by isolated stimuli. The extra‐inhibition induced by PMv stimulation remained even after cTBS which depressed M1 excitability. The extra‐inhibition suggests the existence of input convergence between peripheral afferents and corticospinal inputs onto inhibitory propriospinal neurons. Our results support the existence of direct descending influence from M1 and PMv onto inhibitory propriospinal neurons in humans, possibly though direct corticospinal or via reticulospinal inputs. |
format | Online Article Text |
id | pubmed-5661226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56612262017-11-01 Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans Giboin, Louis‐Solal Sangari, Sina Lackmy‐Vallée, Alexandra Messé, Arnaud Pradat‐Diehl, Pascale Marchand‐Pauvert, Véronique Physiol Rep Original Research Inhibitory propriospinal neurons with diffuse projections onto upper limb motoneurons have been revealed in humans using peripheral nerve stimulation. This system is supposed to mediate descending inhibition to motoneurons, to prevent unwilling muscle activity. However, the corticospinal control onto inhibitory propriospinal neurons has never been investigated so far in humans. We addressed the question whether inhibitory cervical propriospinal neurons receive corticospinal inputs from primary motor (M1) and ventral premotor areas (PMv) using spatial facilitation method. We have stimulated M1 or PMv using transcranial magnetic stimulation (TMS) and/or median nerve whose afferents are known to activate inhibitory propriospinal neurons. Potential input convergence was evaluated by studying the change in monosynaptic reflexes produced in wrist extensor electromyogram (EMG) after isolated and combined stimuli in 17 healthy subjects. Then, to determine whether PMv controlled propriospinal neurons directly or through PMv‐M1 interaction, we tested the connectivity between PMv and propriospinal neurons after a functional disruption of M1 produced by paired continuous theta burst stimulation (cTBS). TMS over M1 or PMv produced reflex inhibition significantly stronger on combined stimulations, compared to the algebraic sum of effects induced by isolated stimuli. The extra‐inhibition induced by PMv stimulation remained even after cTBS which depressed M1 excitability. The extra‐inhibition suggests the existence of input convergence between peripheral afferents and corticospinal inputs onto inhibitory propriospinal neurons. Our results support the existence of direct descending influence from M1 and PMv onto inhibitory propriospinal neurons in humans, possibly though direct corticospinal or via reticulospinal inputs. John Wiley and Sons Inc. 2017-10-30 /pmc/articles/PMC5661226/ /pubmed/29084839 http://dx.doi.org/10.14814/phy2.13387 Text en © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Giboin, Louis‐Solal Sangari, Sina Lackmy‐Vallée, Alexandra Messé, Arnaud Pradat‐Diehl, Pascale Marchand‐Pauvert, Véronique Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title | Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title_full | Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title_fullStr | Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title_full_unstemmed | Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title_short | Corticospinal control from M1 and PMv areas on inhibitory cervical propriospinal neurons in humans |
title_sort | corticospinal control from m1 and pmv areas on inhibitory cervical propriospinal neurons in humans |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661226/ https://www.ncbi.nlm.nih.gov/pubmed/29084839 http://dx.doi.org/10.14814/phy2.13387 |
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