Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease

Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element‐1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent repression of neuronal g...

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Detalles Bibliográficos
Autores principales: Chen, Guo‐Lin, Ma, Qi, Goswami, Dharmendra, Shang, Jianyu, Miller, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661251/
https://www.ncbi.nlm.nih.gov/pubmed/28524599
http://dx.doi.org/10.1111/jcmm.13209

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