Cargando…

Peripheral blood aspirates overexpressing IGF‐I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes

Implantation of peripheral blood aspirates induced towards chondrogenic differentiation upon genetic modification in sites of articular cartilage injury may represent a powerful strategy to enhance cartilage repair. Such a single‐step approach may be less invasive than procedures based on the use of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frisch, Janina, Orth, Patrick, Rey‐Rico, Ana, Venkatesan, Jagadeesh Kumar, Schmitt, Gertrud, Madry, Henning, Kohn, Dieter, Cucchiarini, Magali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661259/ https://www.ncbi.nlm.nih.gov/pubmed/28467017 http://dx.doi.org/10.1111/jcmm.13190

Ejemplares similares

TGF‐β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2017)

Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates
por: Tao, Ke, et al.
Publicado: (2017)

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells
por: Tao, Ke, et al.
Publicado: (2016)

Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno‐Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor‐β Gene Delivery
por: Frisch, Janina, et al.
Publicado: (2016)

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2013)

rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
por: Madry, Henning, et al.
Publicado: (2012)

Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2020)

Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
por: Daniels, Oliver, et al.
Publicado: (2019)

Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2018)

Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-β and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

rAAV-mediated overexpression of TGF-β via vector delivery in polymeric micelles stimulates the biological and reparative activities of human articular chondrocytes in vitro and in a human osteochondral defect model
por: Rey-Rico, Ana, et al.
Publicado: (2017)

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
por: Frisch, Janina, et al.
Publicado: (2014)

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2012)

Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
por: Alvarez-Rivera, Fernando, et al.
Publicado: (2020)

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Meng, Weikun, et al.
Publicado: (2020)

Current perspectives in stem cell research for knee cartilage repair
por: Orth, Patrick, et al.
Publicado: (2014)

rAAV TGF-β and FGF-2 Overexpression via pNaSS-Grafted PCL Films Stimulates the Reparative Activities of Human ACL Fibroblasts
por: Amini, Mahnaz, et al.
Publicado: (2023)

Therapeutic Delivery of rAAV sox9 via Polymeric Micelles Counteracts the Effects of Osteoarthritis-Associated Inflammatory Cytokines in Human Articular Chondrocytes
por: Urich, Jonas, et al.
Publicado: (2020)

Scaffold-Mediated Gene Delivery for Osteochondral Repair
por: Madry, Henning, et al.
Publicado: (2020)

Cytotoxic effects of different mouthwash solutions on primary human articular chondrocytes and normal human articular cartilage – an in vitro study
por: Cai, Xiaoyu, et al.
Publicado: (2023)

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
por: Madry, Henning, et al.
Publicado: (2017)

Advances in Human Mitochondria-Based Therapies
por: Zhong, Gang, et al.
Publicado: (2022)

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?
por: Velot, Émilie, et al.
Publicado: (2021)

Gene Therapy for Cartilage Repair
por: Madry, Henning, et al.
Publicado: (2011)

Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair
por: Gao, Liang, et al.
Publicado: (2017)

Translational applications of photopolymerizable hydrogels for cartilage repair
por: Meng, Weikun, et al.
Publicado: (2019)

Small-Diameter Subchondral Drilling Improves DNA and Proteoglycan Content of the Cartilaginous Repair Tissue in a Large Animal Model of a Full-Thickness Chondral Defect
por: Orth, Patrick, et al.
Publicado: (2020)

Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9
por: Okada, Hironori, et al.
Publicado: (2013)

Differential effects of two MRI contrast agents on the integrity and distribution of rAAV2 and rAAV5 in the rat striatum
por: Osting, Sue, et al.
Publicado: (2014)

Systemic IGF-1 gene delivery by rAAV9 improves spontaneous autoimmune peripheral polyneuropathy (SAPP)
por: Gao, Tong, et al.
Publicado: (2018)

rAAV8 and rAAV9-Mediated Long-Term Muscle Transduction with Tacrolimus (FK506) in Non-Human Primates
por: Ishii, Akiko, et al.
Publicado: (2020)

Extracorporeal Delivery of rAAV with Metabolic Exchange and Oxygenation
por: Bieber, Scott, et al.
Publicado: (2013)

rAAV-delivered PTEN therapeutics for prostate cancer
por: Ai, Jianzhong, et al.
Publicado: (2021)

Clinical potential and challenges of using genetically modified cells for articular cartilage repair
por: Madry, Henning, et al.
Publicado: (2011)

Advanced Gene Therapy Strategies for the Repair of ACL Injuries
por: Amini, Mahnaz, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ultpoua87elcrq2tu8huu4e5u9