The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery

Vasoplegic syndrome is a well-recognized complication during cardiopulmonary bypass (CPB) and is associated with increased morbidity and mortality, especially when refractory to conventional vasoconstrictor therapy. This is the first reported case of vasoplegia on CPB unresponsive to methylene blue...

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Autores principales: Cai, Yi, Mack, Anwar, Ladlie, Beth L, Martin, Archer Kilbourne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661322/
https://www.ncbi.nlm.nih.gov/pubmed/28994688
http://dx.doi.org/10.4103/aca.ACA_88_17
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author Cai, Yi
Mack, Anwar
Ladlie, Beth L
Martin, Archer Kilbourne
author_facet Cai, Yi
Mack, Anwar
Ladlie, Beth L
Martin, Archer Kilbourne
author_sort Cai, Yi
collection PubMed
description Vasoplegic syndrome is a well-recognized complication during cardiopulmonary bypass (CPB) and is associated with increased morbidity and mortality, especially when refractory to conventional vasoconstrictor therapy. This is the first reported case of vasoplegia on CPB unresponsive to methylene blue whereas responsive to hydroxocobalamin, which indicates that the effect of hydroxocobalamin outside of the nitric oxide system is significant or that the two drugs have a synergistic effect in one or multiple mechanisms.
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spelling pubmed-56613222017-11-09 The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery Cai, Yi Mack, Anwar Ladlie, Beth L Martin, Archer Kilbourne Ann Card Anaesth Case Report Vasoplegic syndrome is a well-recognized complication during cardiopulmonary bypass (CPB) and is associated with increased morbidity and mortality, especially when refractory to conventional vasoconstrictor therapy. This is the first reported case of vasoplegia on CPB unresponsive to methylene blue whereas responsive to hydroxocobalamin, which indicates that the effect of hydroxocobalamin outside of the nitric oxide system is significant or that the two drugs have a synergistic effect in one or multiple mechanisms. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5661322/ /pubmed/28994688 http://dx.doi.org/10.4103/aca.ACA_88_17 Text en Copyright: © 2017 Annals of Cardiac Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Cai, Yi
Mack, Anwar
Ladlie, Beth L
Martin, Archer Kilbourne
The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title_full The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title_fullStr The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title_full_unstemmed The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title_short The Use of Intravenous Hydroxocobalamin as a Rescue in Methylene Blue-resistant Vasoplegic Syndrome in Cardiac Surgery
title_sort use of intravenous hydroxocobalamin as a rescue in methylene blue-resistant vasoplegic syndrome in cardiac surgery
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661322/
https://www.ncbi.nlm.nih.gov/pubmed/28994688
http://dx.doi.org/10.4103/aca.ACA_88_17
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