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Translational Research in Oncology: Implications for Palliative Care

The label “translational research” (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the laboratory bench and its use at the clinical bedside. This is claimed to help society harves...

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Autor principal: Ghoshal, Arunangshu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661352/
https://www.ncbi.nlm.nih.gov/pubmed/29123356
http://dx.doi.org/10.4103/IJPC.IJPC_88_17
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author Ghoshal, Arunangshu
author_facet Ghoshal, Arunangshu
author_sort Ghoshal, Arunangshu
collection PubMed
description The label “translational research” (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the laboratory bench and its use at the clinical bedside. This is claimed to help society harvest the benefits of its investments in scientific research. The past decade has witnessed a remarkable acceleration in the pace of translational cancer medicine – genome sequencing of various human cancers has been broadly deployed in drug discovery programs, diagnostic tests have been developed to predict molecularly targeted anticancer agents, advent of cancer immunotherapies, an enhanced appreciation of the complex interactions that exist between tumor cells and their microenvironment have revolutionized the management of cancers. Treatment for cancer and palliative care (PC) go hand in hand and the role of TR in PC can no longer be ignored. This paper discusses about the scientific discourse of TR in cancer care and its implications for the practice of PC. It starts with a brief reconstruction of the history of the concept and subsequently unravels how the label is used in clinical/research practice. In conclusion, TR seems to be driven by a changed relationship between science and society. “Translation” has become important because society is thought to deserve a tangible return in terms of health and quality of life on its investment in basic biomedical science.
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spelling pubmed-56613522017-11-09 Translational Research in Oncology: Implications for Palliative Care Ghoshal, Arunangshu Indian J Palliat Care Perspectives The label “translational research” (TR) has become ever more popular in the biomedical domain in recent years. It is usually presented as an attempt to bridge a supposed gap between knowledge produced at the laboratory bench and its use at the clinical bedside. This is claimed to help society harvest the benefits of its investments in scientific research. The past decade has witnessed a remarkable acceleration in the pace of translational cancer medicine – genome sequencing of various human cancers has been broadly deployed in drug discovery programs, diagnostic tests have been developed to predict molecularly targeted anticancer agents, advent of cancer immunotherapies, an enhanced appreciation of the complex interactions that exist between tumor cells and their microenvironment have revolutionized the management of cancers. Treatment for cancer and palliative care (PC) go hand in hand and the role of TR in PC can no longer be ignored. This paper discusses about the scientific discourse of TR in cancer care and its implications for the practice of PC. It starts with a brief reconstruction of the history of the concept and subsequently unravels how the label is used in clinical/research practice. In conclusion, TR seems to be driven by a changed relationship between science and society. “Translation” has become important because society is thought to deserve a tangible return in terms of health and quality of life on its investment in basic biomedical science. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5661352/ /pubmed/29123356 http://dx.doi.org/10.4103/IJPC.IJPC_88_17 Text en Copyright: © 2017 Indian Journal of Palliative Care http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Perspectives
Ghoshal, Arunangshu
Translational Research in Oncology: Implications for Palliative Care
title Translational Research in Oncology: Implications for Palliative Care
title_full Translational Research in Oncology: Implications for Palliative Care
title_fullStr Translational Research in Oncology: Implications for Palliative Care
title_full_unstemmed Translational Research in Oncology: Implications for Palliative Care
title_short Translational Research in Oncology: Implications for Palliative Care
title_sort translational research in oncology: implications for palliative care
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661352/
https://www.ncbi.nlm.nih.gov/pubmed/29123356
http://dx.doi.org/10.4103/IJPC.IJPC_88_17
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