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Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer

The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 express...

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Autores principales: Zhang, Shizhen, Lei, Rui, Wu, Jingjing, Shan, Jinlan, Hu, Zujian, Chen, Lirong, Ren, Xingchang, Yao, Lifang, Wang, Jian, Wang, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661362/
https://www.ncbi.nlm.nih.gov/pubmed/29113200
http://dx.doi.org/10.3892/ol.2017.6963
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author Zhang, Shizhen
Lei, Rui
Wu, Jingjing
Shan, Jinlan
Hu, Zujian
Chen, Lirong
Ren, Xingchang
Yao, Lifang
Wang, Jian
Wang, Xiaochen
author_facet Zhang, Shizhen
Lei, Rui
Wu, Jingjing
Shan, Jinlan
Hu, Zujian
Chen, Lirong
Ren, Xingchang
Yao, Lifang
Wang, Jian
Wang, Xiaochen
author_sort Zhang, Shizhen
collection PubMed
description The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was determined by performing immunohistochemistry on surgical tissue samples of 273 BC specimens from the Second Affiliated Hospital of Zhejiang University (Zhejiang, China) and 310 BCs from the National Engineering Center for Biochip (Shanghai, China). Kaplan-Meier analysis and Cox proportional hazard model were employed to analyze the survivability. HMGA1 expression was significantly associated with tumor histological degree and body mass index (BMI). However, HMGA1 expression showed no prognostic value in patients with BC. Combined evaluation of HMGA1 expression and high BMI (≥24 kg/m(2)) predicted worse overall survival of BC. Therefore, HMGA1 and BMI were considered to serve synergistic roles in the development and progression of BC, and combined evaluation of HMGA1 expression and high BMI may be an effective marker in predicting poor prognosis of BC patients.
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spelling pubmed-56613622017-11-06 Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer Zhang, Shizhen Lei, Rui Wu, Jingjing Shan, Jinlan Hu, Zujian Chen, Lirong Ren, Xingchang Yao, Lifang Wang, Jian Wang, Xiaochen Oncol Lett Articles The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was determined by performing immunohistochemistry on surgical tissue samples of 273 BC specimens from the Second Affiliated Hospital of Zhejiang University (Zhejiang, China) and 310 BCs from the National Engineering Center for Biochip (Shanghai, China). Kaplan-Meier analysis and Cox proportional hazard model were employed to analyze the survivability. HMGA1 expression was significantly associated with tumor histological degree and body mass index (BMI). However, HMGA1 expression showed no prognostic value in patients with BC. Combined evaluation of HMGA1 expression and high BMI (≥24 kg/m(2)) predicted worse overall survival of BC. Therefore, HMGA1 and BMI were considered to serve synergistic roles in the development and progression of BC, and combined evaluation of HMGA1 expression and high BMI may be an effective marker in predicting poor prognosis of BC patients. D.A. Spandidos 2017-11 2017-09-15 /pmc/articles/PMC5661362/ /pubmed/29113200 http://dx.doi.org/10.3892/ol.2017.6963 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Shizhen
Lei, Rui
Wu, Jingjing
Shan, Jinlan
Hu, Zujian
Chen, Lirong
Ren, Xingchang
Yao, Lifang
Wang, Jian
Wang, Xiaochen
Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title_full Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title_fullStr Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title_full_unstemmed Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title_short Role of high mobility group A1 and body mass index in the prognosis of patients with breast cancer
title_sort role of high mobility group a1 and body mass index in the prognosis of patients with breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661362/
https://www.ncbi.nlm.nih.gov/pubmed/29113200
http://dx.doi.org/10.3892/ol.2017.6963
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