10H-3,6-Diazaphenothiazine induces G(2)/M phase cell cycle arrest and caspase-dependent apoptosis and inhibits cell invasion of A2780 ovarian carcinoma cells through the regulation of NF-κB and (BIRC6-XIAP) complexes

The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the fundamental chemotherapy provides promising anticancer activities, it is associated with severe side effects. The derivative of phenothiazine, namely,...

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Detalles Bibliográficos
Autores principales: Zhang, Jianxin, Ming, Chen, Zhang, Wenzhi, Okechukwu, Patrick Nwabueze, Morak-Młodawska, Beata, Pluta, Krystian, Jeleń, Małgorzata, Akim, Abdah Md, Ang, Kok-Pian, Ooi, Kah Kooi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661483/
https://www.ncbi.nlm.nih.gov/pubmed/29123378
http://dx.doi.org/10.2147/DDDT.S144415

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