Low-dose valproic acid with low-dose gemcitabine augments MHC class I-related chain A/B expression without inducing the release of soluble MHC class I-related chain A/B

To improve natural killer group 2 member D (NKG2D)-dependent cytotoxicity, the inhibition of cleavage and release of major histocompatibility complex class 1-related chain (MIC) molecules from the tumor surface are required. Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, is able to ind...

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Detalles Bibliográficos
Autores principales: Miyashita, Tomoharu, Miki, Kenji, Kamigaki, Takashi, Makino, Isamu, Tajima, Hidehiro, Nakanuma, Shinichi, Hayashi, Hironori, Takamura, Hiroyuki, Fushida, Sachio, Ahmed, Ali K., Harmon, John W., Ohta, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661604/
https://www.ncbi.nlm.nih.gov/pubmed/29113227
http://dx.doi.org/10.3892/ol.2017.6943

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