Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance

Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups.

Detalles Bibliográficos
Autor principal: Pei, Duanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661622/
https://www.ncbi.nlm.nih.gov/pubmed/29263917
http://dx.doi.org/10.1038/sigtrans.2017.14
Descripción
Sumario:Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups.

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