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Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance
Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups.
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661622/ https://www.ncbi.nlm.nih.gov/pubmed/29263917 http://dx.doi.org/10.1038/sigtrans.2017.14 |
| _version_ | 1783274517435514880 |
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| author | Pei, Duanqing |
| author_facet | Pei, Duanqing |
| author_sort | Pei, Duanqing |
| collection | PubMed |
| description | Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups. |
| format | Online Article Text |
| id | pubmed-5661622 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-56616222017-12-20 Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance Pei, Duanqing Signal Transduct Target Ther Perspective Recently, three groups independently identified ubiquitin-specific peptidase 21 (USP21) as an efficient deubiquitylase that reverses Nanog polyubiquitylation and stabilizes Nanog protein. In this preview, I have summarized the work of these three groups. Nature Publishing Group 2017-04-21 /pmc/articles/PMC5661622/ /pubmed/29263917 http://dx.doi.org/10.1038/sigtrans.2017.14 Text en Copyright © 2017 The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| spellingShingle | Perspective Pei, Duanqing Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title | Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title_full | Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title_fullStr | Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title_full_unstemmed | Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title_short | Deubiquitylating Nanog: novel role of USP21 in embryonic stem cell maintenance |
| title_sort | deubiquitylating nanog: novel role of usp21 in embryonic stem cell maintenance |
| topic | Perspective |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661622/ https://www.ncbi.nlm.nih.gov/pubmed/29263917 http://dx.doi.org/10.1038/sigtrans.2017.14 |
| work_keys_str_mv | AT peiduanqing deubiquitylatingnanognovelroleofusp21inembryonicstemcellmaintenance |