Fibromodulin reduces scar formation in adult cutaneous wounds by eliciting a fetal-like phenotype

Blocking transforming growth factor (TGF)β1 signal transduction has been a central strategy for scar reduction; however, this approach appears to be minimally effective. Here, we show that fibromodulin (FMOD), a 59-kD small leucine-rich proteoglycan critical for normal collagen fibrillogenesis, sign...

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Detalles Bibliográficos
Autores principales: Zheng, Zhong, James, Aaron W, Li, Chenshuang, Jiang, Wenlu, Wang, Joyce Z, Chang, Grace X, Lee, Kevin S, Chen, Feng, Berthiaume, Emily A, Chen, Yao, Pan, Hsin Chuan, Chen, Eric C, Li, Weiming, Zhao, Zhihe, Zhang, Xinli, Ting, Kang, Soo, Chia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661627/
https://www.ncbi.nlm.nih.gov/pubmed/29201497
http://dx.doi.org/10.1038/sigtrans.2017.50

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