Peptide-substituted oligonucleotide synthesis and non-toxic, passive cell delivery

Chemically modified oligodeoxynucleotides (ODNs) are known to modulate gene expression by interacting with RNA. An efficient approach for synthesizing amino acid- or peptide-substituted triazolylphosphonate analogs (TP ODNs) has been developed to provide improved stability and cell uptake. The chemi...

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Detalles Bibliográficos
Autores principales: Shang, Shiying, Monfregola, Luca, Caruthers, Marvin H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661639/
https://www.ncbi.nlm.nih.gov/pubmed/29263901
http://dx.doi.org/10.1038/sigtrans.2016.19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661639/
https://www.ncbi.nlm.nih.gov/pubmed/29263901
http://dx.doi.org/10.1038/sigtrans.2016.19

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