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STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia

The pathogenesis of chronic lymphocytic leukemia (CLL) is poorly understood and it remains incurable with current therapies. We have previously shown that nanoliposomal C6-ceramide (CNL) is an effective therapy in an in vivo murine model of CLL. However, the key signaling pathways mediating CNL-indu...

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Detalles Bibliográficos
Autores principales:	Doshi, Ushma A, Shaw, Jeremy, Fox, Todd E, Claxton, David F, Loughran, Thomas P, Kester, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661641/ https://www.ncbi.nlm.nih.gov/pubmed/29263930 http://dx.doi.org/10.1038/sigtrans.2017.51

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