USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). Stabilization of Nanog proteins is essential for ESCs. The ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to...

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Detalles Bibliográficos
Autores principales: Liu, Xingyu, Yao, Yuying, Ding, Huiguo, Han, Chuanchun, Chen, Yuhan, Zhang, Yuan, Wang, Chanjuan, Zhang, Xin, Zhang, Yiling, Zhai, Yun, Wang, Ping, Wei, Wenyi, Zhang, Jing, Zhang, Lingqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661642/
https://www.ncbi.nlm.nih.gov/pubmed/29263902
http://dx.doi.org/10.1038/sigtrans.2016.24

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