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Sensory TRP channels contribute differentially to skin inflammation and persistent itch

Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse...

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Autores principales: Feng, Jing, Yang, Pu, Mack, Madison R., Dryn, Dariia, Luo, Jialie, Gong, Xuan, Liu, Shenbin, Oetjen, Landon K., Zholos, Alexander V., Mei, Zhinan, Yin, Shijin, Kim, Brian S., Hu, Hongzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661746/
https://www.ncbi.nlm.nih.gov/pubmed/29081531
http://dx.doi.org/10.1038/s41467-017-01056-8
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author Feng, Jing
Yang, Pu
Mack, Madison R.
Dryn, Dariia
Luo, Jialie
Gong, Xuan
Liu, Shenbin
Oetjen, Landon K.
Zholos, Alexander V.
Mei, Zhinan
Yin, Shijin
Kim, Brian S.
Hu, Hongzhen
author_facet Feng, Jing
Yang, Pu
Mack, Madison R.
Dryn, Dariia
Luo, Jialie
Gong, Xuan
Liu, Shenbin
Oetjen, Landon K.
Zholos, Alexander V.
Mei, Zhinan
Yin, Shijin
Kim, Brian S.
Hu, Hongzhen
author_sort Feng, Jing
collection PubMed
description Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD. Our results demonstrate that persistent itch and inflammation are mediated by distinct cellular and molecular mechanisms in a mouse model of ACD. Identification of distinct roles of TRPA1 and TRPV1 in regulating itch and inflammation may provide new insights into the pathophysiology and treatment of chronic itch and inflammation in ACD patients.
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spelling pubmed-56617462017-11-01 Sensory TRP channels contribute differentially to skin inflammation and persistent itch Feng, Jing Yang, Pu Mack, Madison R. Dryn, Dariia Luo, Jialie Gong, Xuan Liu, Shenbin Oetjen, Landon K. Zholos, Alexander V. Mei, Zhinan Yin, Shijin Kim, Brian S. Hu, Hongzhen Nat Commun Article Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD. Our results demonstrate that persistent itch and inflammation are mediated by distinct cellular and molecular mechanisms in a mouse model of ACD. Identification of distinct roles of TRPA1 and TRPV1 in regulating itch and inflammation may provide new insights into the pathophysiology and treatment of chronic itch and inflammation in ACD patients. Nature Publishing Group UK 2017-10-30 /pmc/articles/PMC5661746/ /pubmed/29081531 http://dx.doi.org/10.1038/s41467-017-01056-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Feng, Jing
Yang, Pu
Mack, Madison R.
Dryn, Dariia
Luo, Jialie
Gong, Xuan
Liu, Shenbin
Oetjen, Landon K.
Zholos, Alexander V.
Mei, Zhinan
Yin, Shijin
Kim, Brian S.
Hu, Hongzhen
Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_full Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_fullStr Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_full_unstemmed Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_short Sensory TRP channels contribute differentially to skin inflammation and persistent itch
title_sort sensory trp channels contribute differentially to skin inflammation and persistent itch
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661746/
https://www.ncbi.nlm.nih.gov/pubmed/29081531
http://dx.doi.org/10.1038/s41467-017-01056-8
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