Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid

BACKGROUND: Epstein–Barr virus (EBV) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with EBV encephalitis. Also, whenever it is diagnosed, it is always treated symptomatically. CASE REPORT: A case of confirmed EBV encephalitis is presented, which was...

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Autores principales: Zarlasht, Fnu, Salehi, Mashal, Abu-Hishmeh, Mohammad, Khan, Muzammil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661833/
https://www.ncbi.nlm.nih.gov/pubmed/29123419
http://dx.doi.org/10.2147/IJGM.S143335
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author Zarlasht, Fnu
Salehi, Mashal
Abu-Hishmeh, Mohammad
Khan, Muzammil
author_facet Zarlasht, Fnu
Salehi, Mashal
Abu-Hishmeh, Mohammad
Khan, Muzammil
author_sort Zarlasht, Fnu
collection PubMed
description BACKGROUND: Epstein–Barr virus (EBV) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with EBV encephalitis. Also, whenever it is diagnosed, it is always treated symptomatically. CASE REPORT: A case of confirmed EBV encephalitis is presented, which was treated with antiviral therapy resulting in complete clearance of the virus in cerebrospinal fluid and minimal neurologic symptoms after hospital discharge. CONCLUSION: The Infectious Diseases Society of America guidelines state that intravenous acyclovir is not recommended for EBV-related encephalitis. But we reviewed the literature and found similar cases, and we believe that antiviral therapy should be recommended for EBV encephalitis because it is a potentially fatal disease and if left untreated, can lead to raised intracranial pressure, craniotomy and even death.
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spelling pubmed-56618332017-11-09 Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid Zarlasht, Fnu Salehi, Mashal Abu-Hishmeh, Mohammad Khan, Muzammil Int J Gen Med Case Report BACKGROUND: Epstein–Barr virus (EBV) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with EBV encephalitis. Also, whenever it is diagnosed, it is always treated symptomatically. CASE REPORT: A case of confirmed EBV encephalitis is presented, which was treated with antiviral therapy resulting in complete clearance of the virus in cerebrospinal fluid and minimal neurologic symptoms after hospital discharge. CONCLUSION: The Infectious Diseases Society of America guidelines state that intravenous acyclovir is not recommended for EBV-related encephalitis. But we reviewed the literature and found similar cases, and we believe that antiviral therapy should be recommended for EBV encephalitis because it is a potentially fatal disease and if left untreated, can lead to raised intracranial pressure, craniotomy and even death. Dove Medical Press 2017-10-26 /pmc/articles/PMC5661833/ /pubmed/29123419 http://dx.doi.org/10.2147/IJGM.S143335 Text en © 2017 Zarlasht et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Zarlasht, Fnu
Salehi, Mashal
Abu-Hishmeh, Mohammad
Khan, Muzammil
Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title_full Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title_fullStr Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title_full_unstemmed Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title_short Encephalitis treatment – a case report with long-term follow-up of EBV PCR in cerebrospinal fluid
title_sort encephalitis treatment – a case report with long-term follow-up of ebv pcr in cerebrospinal fluid
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661833/
https://www.ncbi.nlm.nih.gov/pubmed/29123419
http://dx.doi.org/10.2147/IJGM.S143335
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