Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-...

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Detalles Bibliográficos
Autores principales: Delatorre, Edson, Mir, Daiana, Bello, Gonzalo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661894/
https://www.ncbi.nlm.nih.gov/pubmed/28876359
http://dx.doi.org/10.1590/0074-02760170299
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author Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
author_facet Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
author_sort Delatorre, Edson
collection PubMed
description A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.
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spelling pubmed-56618942017-11-04 Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity Delatorre, Edson Mir, Daiana Bello, Gonzalo Mem Inst Oswaldo Cruz Letter to the Editor A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results support that the ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas. Instituto Oswaldo Cruz, Ministério da Saúde 2017-11 /pmc/articles/PMC5661894/ /pubmed/28876359 http://dx.doi.org/10.1590/0074-02760170299 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Delatorre, Edson
Mir, Daiana
Bello, Gonzalo
Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title_full Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title_fullStr Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title_full_unstemmed Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title_short Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity
title_sort tracing the origin of the ns1 a188v substitution responsible for recent enhancement of zika virus asian genotype infectivity
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661894/
https://www.ncbi.nlm.nih.gov/pubmed/28876359
http://dx.doi.org/10.1590/0074-02760170299
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