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Cytotoxic activity in cutaneous leishmaniasis
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an infl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Oswaldo Cruz, Ministério da Saúde
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661895/ https://www.ncbi.nlm.nih.gov/pubmed/29091132 http://dx.doi.org/10.1590/0074-02760170109 |
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author | Campos, Taís M Costa, Rúbia Passos, Sara Carvalho, Lucas P |
author_facet | Campos, Taís M Costa, Rúbia Passos, Sara Carvalho, Lucas P |
author_sort | Campos, Taís M |
collection | PubMed |
description | Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease. |
format | Online Article Text |
id | pubmed-5661895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Instituto Oswaldo Cruz, Ministério da Saúde |
record_format | MEDLINE/PubMed |
spelling | pubmed-56618952017-11-04 Cytotoxic activity in cutaneous leishmaniasis Campos, Taís M Costa, Rúbia Passos, Sara Carvalho, Lucas P Mem Inst Oswaldo Cruz Review Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease. Instituto Oswaldo Cruz, Ministério da Saúde 2017-11 /pmc/articles/PMC5661895/ /pubmed/29091132 http://dx.doi.org/10.1590/0074-02760170109 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Campos, Taís M Costa, Rúbia Passos, Sara Carvalho, Lucas P Cytotoxic activity in cutaneous leishmaniasis |
title | Cytotoxic activity in cutaneous leishmaniasis |
title_full | Cytotoxic activity in cutaneous leishmaniasis |
title_fullStr | Cytotoxic activity in cutaneous leishmaniasis |
title_full_unstemmed | Cytotoxic activity in cutaneous leishmaniasis |
title_short | Cytotoxic activity in cutaneous leishmaniasis |
title_sort | cytotoxic activity in cutaneous leishmaniasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661895/ https://www.ncbi.nlm.nih.gov/pubmed/29091132 http://dx.doi.org/10.1590/0074-02760170109 |
work_keys_str_mv | AT campostaism cytotoxicactivityincutaneousleishmaniasis AT costarubia cytotoxicactivityincutaneousleishmaniasis AT passossara cytotoxicactivityincutaneousleishmaniasis AT carvalholucasp cytotoxicactivityincutaneousleishmaniasis |