Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications

BACKGROUND: Next-generation sequencing (NGS) of cancer gene panels are widely applied to enable personalized cancer therapy and to identify novel oncogenic mutations. METHODS: We performed targeted NGS on 932 clinical cases of non-small-cell lung cancers (NSCLCs) using the Ion AmpliSeq™ Cancer Hotsp...

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Detalles Bibliográficos
Autores principales: Li, Shuyu D., Ma, Meng, Li, Hui, Waluszko, Aneta, Sidorenko, Tatyana, Schadt, Eric E., Zhang, David Y., Chen, Rong, Ye, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662094/
https://www.ncbi.nlm.nih.gov/pubmed/29082853
http://dx.doi.org/10.1186/s13073-017-0478-1

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