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Mellitate: A multivalent anion with extreme charge density causes rapid aggregation and misfolding of wild type lysozyme at neutral pH

Due to its symmetric structure and abundance of carboxyl groups, mellitic acid (MA–benzenehexacarboxylic acid) has an uncommon capacity to form highly ordered molecular networks. Dissolved in water, MA dissociates to yield various mellitate anions with pronounced tendencies to form complexes with ca...

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Detalles Bibliográficos
Autores principales: Ścibisz, Grzegorz, Dec, Robert, Dzwolak, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662172/
https://www.ncbi.nlm.nih.gov/pubmed/29084264
http://dx.doi.org/10.1371/journal.pone.0187328