The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect

Many DNA lesions associated with lymphoid malignancies are linked to off-target cleavage by the RAG1/2 recombinase. However, off-target cleavage has mostly been analyzed in the context of DNA repair defects, confounding any mechanistic understanding of cleavage deregulation. We identified a conserve...

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Detalles Bibliográficos
Autores principales: Hewitt, Susannah L., Wong, Jason B., Lee, Ji-Hoon, Nishana, Mayilaadumveettil, Chen, Hongxi, Coussens, Marc, Arnal, Suzzette M., Blumenberg, Lili M., Roth, David B., Paull, Tanya T., Skok, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662208/
https://www.ncbi.nlm.nih.gov/pubmed/29069605
http://dx.doi.org/10.1016/j.celrep.2017.09.084

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