TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

Tumor-associated macrophages (TAMs) are heterogeneous and can adopt a spectrum of activation states between pro-inflammatory and pro-tumorigenic in response to the microenvironment. We have previously shown that TTI-621, a soluble SIRPαFc fusion protein that blocks the CD47 “do-not-eat” signal, prom...

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Detalles Bibliográficos
Autores principales: Lin, Gloria H. Y., Chai, Vien, Lee, Vivian, Dodge, Karen, Truong, Tran, Wong, Mark, Johnson, Lisa D., Linderoth, Emma, Pang, Xinli, Winston, Jeff, Petrova, Penka S., Uger, Robert A., Viller, Natasja N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662218/
https://www.ncbi.nlm.nih.gov/pubmed/29084248
http://dx.doi.org/10.1371/journal.pone.0187262

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