Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication

DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA pol...

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Autores principales: Ignatov, A.V., Bondarenko, K.A., Makarova, A.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662270/
https://www.ncbi.nlm.nih.gov/pubmed/29104772
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author Ignatov, A.V.
Bondarenko, K.A.
Makarova, A.V.
author_facet Ignatov, A.V.
Bondarenko, K.A.
Makarova, A.V.
author_sort Ignatov, A.V.
collection PubMed
description DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis.
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spelling pubmed-56622702017-11-03 Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication Ignatov, A.V. Bondarenko, K.A. Makarova, A.V. Acta Naturae Research Article DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis. A.I. Gordeyev 2017 /pmc/articles/PMC5662270/ /pubmed/29104772 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ignatov, A.V.
Bondarenko, K.A.
Makarova, A.V.
Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title_full Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title_fullStr Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title_full_unstemmed Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title_short Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
title_sort non-bulky lesions in human dna: the ways of formation, repair, and replication
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662270/
https://www.ncbi.nlm.nih.gov/pubmed/29104772
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