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Proteasomes in Protein Homeostasis of Pluripotent Stem Cells

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are subjects of high interest not only in basic research, but also in various applied fields, particularly, in regenerative medicine. Despite the tremendous interest to these cells, the molecular mechanisms that control protein h...

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Autores principales: Selenina, A.V., Tsimokha, A.S., Tomilin, A.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662272/
https://www.ncbi.nlm.nih.gov/pubmed/29104774
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author Selenina, A.V.
Tsimokha, A.S.
Tomilin, A.N.
author_facet Selenina, A.V.
Tsimokha, A.S.
Tomilin, A.N.
author_sort Selenina, A.V.
collection PubMed
description Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are subjects of high interest not only in basic research, but also in various applied fields, particularly, in regenerative medicine. Despite the tremendous interest to these cells, the molecular mechanisms that control protein homeostasis in these cells remain largely unknown. The ubiquitin-proteasome system (UPS) acts via post-translational protein modifications and protein degradation and, therefore, is involved in the control of virtually all cellular processes: cell cycle, self-renewal, signal transduction, transcription, translation, oxidative stress, immune response, apoptosis, etc. Therefore, studying the biological role and action mechanisms of the UPS in pluripotent cells will help to better understand the biology of cells, as well as to develop novel approaches for regenerative medicine.
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spelling pubmed-56622722017-11-03 Proteasomes in Protein Homeostasis of Pluripotent Stem Cells Selenina, A.V. Tsimokha, A.S. Tomilin, A.N. Acta Naturae Research Article Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are subjects of high interest not only in basic research, but also in various applied fields, particularly, in regenerative medicine. Despite the tremendous interest to these cells, the molecular mechanisms that control protein homeostasis in these cells remain largely unknown. The ubiquitin-proteasome system (UPS) acts via post-translational protein modifications and protein degradation and, therefore, is involved in the control of virtually all cellular processes: cell cycle, self-renewal, signal transduction, transcription, translation, oxidative stress, immune response, apoptosis, etc. Therefore, studying the biological role and action mechanisms of the UPS in pluripotent cells will help to better understand the biology of cells, as well as to develop novel approaches for regenerative medicine. A.I. Gordeyev 2017 /pmc/articles/PMC5662272/ /pubmed/29104774 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Selenina, A.V.
Tsimokha, A.S.
Tomilin, A.N.
Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title_full Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title_fullStr Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title_full_unstemmed Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title_short Proteasomes in Protein Homeostasis of Pluripotent Stem Cells
title_sort proteasomes in protein homeostasis of pluripotent stem cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662272/
https://www.ncbi.nlm.nih.gov/pubmed/29104774
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