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Predicting the Evolutionary Variability of the Influenza A Virus
The influenza A virus remains one of the most common and dangerous human health concerns due to its rapid evolutionary dynamics. Since the evolutionary changes of influenza A viruses can be traced in real time, the last decade has seen a surge in research on influenza A viruses due to an increase in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
A.I. Gordeyev
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662273/ https://www.ncbi.nlm.nih.gov/pubmed/29104775 |
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author | Timofeeva, T.A. Asatryan, M.N. Altstein, A.D. Narodisky, B.S. Gintsburg, A.L. Kaverin, N.V. |
author_facet | Timofeeva, T.A. Asatryan, M.N. Altstein, A.D. Narodisky, B.S. Gintsburg, A.L. Kaverin, N.V. |
author_sort | Timofeeva, T.A. |
collection | PubMed |
description | The influenza A virus remains one of the most common and dangerous human health concerns due to its rapid evolutionary dynamics. Since the evolutionary changes of influenza A viruses can be traced in real time, the last decade has seen a surge in research on influenza A viruses due to an increase in experimental data (selection of escape mutants followed by examination of their phenotypic characteristics and generation of viruses with desired mutations using reverse genetics). Moreover, the advances in our understanding are also attributable to the development of new computational methods based on a phylogenetic analysis of influenza virus strains and mathematical (integro-differential equations, statistical methods, probability-theory-based methods) and simulation modeling. Continuously evolving highly pathogenic influenza A viruses are a serious health concern which necessitates a coupling of theoretical and experimental approaches to predict the evolutionary trends of the influenza A virus, with a focus on the H5 subtype. |
format | Online Article Text |
id | pubmed-5662273 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | A.I. Gordeyev |
record_format | MEDLINE/PubMed |
spelling | pubmed-56622732017-11-03 Predicting the Evolutionary Variability of the Influenza A Virus Timofeeva, T.A. Asatryan, M.N. Altstein, A.D. Narodisky, B.S. Gintsburg, A.L. Kaverin, N.V. Acta Naturae Research Article The influenza A virus remains one of the most common and dangerous human health concerns due to its rapid evolutionary dynamics. Since the evolutionary changes of influenza A viruses can be traced in real time, the last decade has seen a surge in research on influenza A viruses due to an increase in experimental data (selection of escape mutants followed by examination of their phenotypic characteristics and generation of viruses with desired mutations using reverse genetics). Moreover, the advances in our understanding are also attributable to the development of new computational methods based on a phylogenetic analysis of influenza virus strains and mathematical (integro-differential equations, statistical methods, probability-theory-based methods) and simulation modeling. Continuously evolving highly pathogenic influenza A viruses are a serious health concern which necessitates a coupling of theoretical and experimental approaches to predict the evolutionary trends of the influenza A virus, with a focus on the H5 subtype. A.I. Gordeyev 2017 /pmc/articles/PMC5662273/ /pubmed/29104775 Text en Copyright ® 2017 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Timofeeva, T.A. Asatryan, M.N. Altstein, A.D. Narodisky, B.S. Gintsburg, A.L. Kaverin, N.V. Predicting the Evolutionary Variability of the Influenza A Virus |
title | Predicting the Evolutionary Variability of the Influenza A Virus |
title_full | Predicting the Evolutionary Variability of the Influenza A Virus |
title_fullStr | Predicting the Evolutionary Variability of the Influenza A Virus |
title_full_unstemmed | Predicting the Evolutionary Variability of the Influenza A Virus |
title_short | Predicting the Evolutionary Variability of the Influenza A Virus |
title_sort | predicting the evolutionary variability of the influenza a virus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662273/ https://www.ncbi.nlm.nih.gov/pubmed/29104775 |
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