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Exploratory search during directed navigation in C. elegans and Drosophila larva
Many organisms—from bacteria to nematodes to insect larvae—navigate their environments by biasing random movements. In these organisms, navigation in isotropic environments can be characterized as an essentially diffusive and undirected process. In stimulus gradients, movement decisions are biased t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662291/ https://www.ncbi.nlm.nih.gov/pubmed/29083306 http://dx.doi.org/10.7554/eLife.30503 |
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author | Klein, Mason Krivov, Sergei V Ferrer, Anggie J Luo, Linjiao Samuel, Aravinthan DT Karplus, Martin |
author_facet | Klein, Mason Krivov, Sergei V Ferrer, Anggie J Luo, Linjiao Samuel, Aravinthan DT Karplus, Martin |
author_sort | Klein, Mason |
collection | PubMed |
description | Many organisms—from bacteria to nematodes to insect larvae—navigate their environments by biasing random movements. In these organisms, navigation in isotropic environments can be characterized as an essentially diffusive and undirected process. In stimulus gradients, movement decisions are biased to drive directed navigation toward favorable environments. How does directed navigation in a gradient modulate random exploration either parallel or orthogonal to the gradient? Here, we introduce methods originally used for analyzing protein folding trajectories to study the trajectories of the nematode Caenorhabditis elegans and the Drosophila larva in isotropic environments, as well as in thermal and chemical gradients. We find that the statistics of random exploration in any direction are little affected by directed movement along a stimulus gradient. A key constraint on the behavioral strategies of these organisms appears to be the preservation of their capacity to continuously explore their environments in all directions even while moving toward favorable conditions. |
format | Online Article Text |
id | pubmed-5662291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-56622912017-11-01 Exploratory search during directed navigation in C. elegans and Drosophila larva Klein, Mason Krivov, Sergei V Ferrer, Anggie J Luo, Linjiao Samuel, Aravinthan DT Karplus, Martin eLife Computational and Systems Biology Many organisms—from bacteria to nematodes to insect larvae—navigate their environments by biasing random movements. In these organisms, navigation in isotropic environments can be characterized as an essentially diffusive and undirected process. In stimulus gradients, movement decisions are biased to drive directed navigation toward favorable environments. How does directed navigation in a gradient modulate random exploration either parallel or orthogonal to the gradient? Here, we introduce methods originally used for analyzing protein folding trajectories to study the trajectories of the nematode Caenorhabditis elegans and the Drosophila larva in isotropic environments, as well as in thermal and chemical gradients. We find that the statistics of random exploration in any direction are little affected by directed movement along a stimulus gradient. A key constraint on the behavioral strategies of these organisms appears to be the preservation of their capacity to continuously explore their environments in all directions even while moving toward favorable conditions. eLife Sciences Publications, Ltd 2017-10-30 /pmc/articles/PMC5662291/ /pubmed/29083306 http://dx.doi.org/10.7554/eLife.30503 Text en © 2017, Klein et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Klein, Mason Krivov, Sergei V Ferrer, Anggie J Luo, Linjiao Samuel, Aravinthan DT Karplus, Martin Exploratory search during directed navigation in C. elegans and Drosophila larva |
title | Exploratory search during directed navigation in C. elegans and Drosophila larva |
title_full | Exploratory search during directed navigation in C. elegans and Drosophila larva |
title_fullStr | Exploratory search during directed navigation in C. elegans and Drosophila larva |
title_full_unstemmed | Exploratory search during directed navigation in C. elegans and Drosophila larva |
title_short | Exploratory search during directed navigation in C. elegans and Drosophila larva |
title_sort | exploratory search during directed navigation in c. elegans and drosophila larva |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662291/ https://www.ncbi.nlm.nih.gov/pubmed/29083306 http://dx.doi.org/10.7554/eLife.30503 |
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