Effect of cerebral oxygen saturation on postoperative nausea and vomiting in female laparoscopic surgery patients

BACKGROUND: The purpose of this study was to investigate effect of cerebral oxygen saturation (SCTO(2)) on postoperative nausea and vomiting (PONV) in female patients who underwent laparoscopic surgery. METHODS: This study included 90 female patients who underwent laparoscopic surgery (60 cases of gynecological operations and 30 cases of gallbladder operations). All patients were allocated into 3 groups of 30 patients each: group A (gynecological laparoscopic surgery), group B (gynecological laparoscopic surgery with mannitol treatment) and group C (laparoscopic cholecystectomy surgery). Perioperative SCTO(2), mean blood flow velocity of vertebral artery (VM), vascular resistance index of vertebral artery (RI), and PONV (within 48 hours after surgery) were investigated. RESULTS: No differences in age, body weight, operation time, and hemoglobin levels were observed among the patients (P > .05). The SCTO(2) values for groups B and C were lower than those for group A in both brain hemispheres at T(4) and T(5) (P < .05). The VM was higher in group B than in groups A and C at T(3) (P < .05), but differences in VM were not observed between groups B and C at T(4) or T(5). However, the VM of group A was still lower than the other groups (P < .05), and no difference in VM was observed among the 3 groups at T(6) (P > .05). The RI was higher in group C than in groups A and B at T(4) (P < .05). The incidence of PONV within 48 hours after surgery was significantly higher in group A than in the other 2 groups (P < .05). CONCLUSION: Strategies that maintain normal SCTO(2) may reduce the incidence of PONV in female patients who underwent laparoscopy surgery by reducing perioperative intracranial pressure.