Cargando…
Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review
BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complement...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662359/ https://www.ncbi.nlm.nih.gov/pubmed/29049193 http://dx.doi.org/10.1097/MD.0000000000008045 |
_version_ | 1783274626378366976 |
---|---|
author | Gómez-Gómez, Alejandro Loza, Estíbaliz Rosario, Maria Piedad Espinosa, Gerard de Morales, José M. García Ruiz Herreras, Jose M. Muñoz-Fernández, Santiago Cordero-Coma, Miguel |
author_facet | Gómez-Gómez, Alejandro Loza, Estíbaliz Rosario, Maria Piedad Espinosa, Gerard de Morales, José M. García Ruiz Herreras, Jose M. Muñoz-Fernández, Santiago Cordero-Coma, Miguel |
author_sort | Gómez-Gómez, Alejandro |
collection | PubMed |
description | BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complementary hand search was also performed. The selection criteria were as follows: (population) noninfectious AU patients, adults; (intervention) immunomodulatory drugs (any dose, regimen, route of administration, duration of treatment); (outcome) control of inflammation, steroid-sparing effect, AU flares, adverse events, and so on; (study design) systematic literature reviews, randomized controlled trials, and observational studies. The study quality was assessed using the Jadad scale and according to The Oxford Centre for Evidence-based Medicine (update 2009). RESULTS: We included 13 studies of moderate-poor quality, with a mean duration from 5 months to 20 years, and number of AU patients ranging from 9 to 274. Patient's demographic and clinical characteristics were very heterogeneous. In most cases, uveitis anatomic classification criteria and outcomes definitions were unclear. Some of the studies only included AU patients with a systemic disease associated, mostly spondyloarthritis, others, mixed populations (idiopathic and systemic disease associated patients), and in some articles this data is not described. We found that methotrexate, cyclosporine A, azathioprine, adalimumab, and golimumab might prevent AU flares, improve ocular inflammation and visual acuity, and decrease systemic steroids doses. CONCLUSIONS: Although there is a lack of robust evidence, methotrexate, cyclosporine A, azathioprine, adalimumab, and golimumab might be effective in AU patients. |
format | Online Article Text |
id | pubmed-5662359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-56623592017-12-22 Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review Gómez-Gómez, Alejandro Loza, Estíbaliz Rosario, Maria Piedad Espinosa, Gerard de Morales, José M. García Ruiz Herreras, Jose M. Muñoz-Fernández, Santiago Cordero-Coma, Miguel Medicine (Baltimore) 5800 BACKGROUND: To assess the efficacy and safety of immunomodulatory drugs in patients with noninfectious anterior uveitis (AU). METHODS: Systematic review of studies were retrieved from Medline (1961 to March 2016), Embase (1961 to March 2016), and Cochrane Library (up to March 2016), and a complementary hand search was also performed. The selection criteria were as follows: (population) noninfectious AU patients, adults; (intervention) immunomodulatory drugs (any dose, regimen, route of administration, duration of treatment); (outcome) control of inflammation, steroid-sparing effect, AU flares, adverse events, and so on; (study design) systematic literature reviews, randomized controlled trials, and observational studies. The study quality was assessed using the Jadad scale and according to The Oxford Centre for Evidence-based Medicine (update 2009). RESULTS: We included 13 studies of moderate-poor quality, with a mean duration from 5 months to 20 years, and number of AU patients ranging from 9 to 274. Patient's demographic and clinical characteristics were very heterogeneous. In most cases, uveitis anatomic classification criteria and outcomes definitions were unclear. Some of the studies only included AU patients with a systemic disease associated, mostly spondyloarthritis, others, mixed populations (idiopathic and systemic disease associated patients), and in some articles this data is not described. We found that methotrexate, cyclosporine A, azathioprine, adalimumab, and golimumab might prevent AU flares, improve ocular inflammation and visual acuity, and decrease systemic steroids doses. CONCLUSIONS: Although there is a lack of robust evidence, methotrexate, cyclosporine A, azathioprine, adalimumab, and golimumab might be effective in AU patients. Wolters Kluwer Health 2017-10-20 /pmc/articles/PMC5662359/ /pubmed/29049193 http://dx.doi.org/10.1097/MD.0000000000008045 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5800 Gómez-Gómez, Alejandro Loza, Estíbaliz Rosario, Maria Piedad Espinosa, Gerard de Morales, José M. García Ruiz Herreras, Jose M. Muñoz-Fernández, Santiago Cordero-Coma, Miguel Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title | Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title_full | Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title_fullStr | Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title_full_unstemmed | Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title_short | Efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: A systematic literature review |
title_sort | efficacy and safety of immunomodulatory drugs in patients with anterior uveitis: a systematic literature review |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662359/ https://www.ncbi.nlm.nih.gov/pubmed/29049193 http://dx.doi.org/10.1097/MD.0000000000008045 |
work_keys_str_mv | AT gomezgomezalejandro efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT lozaestibaliz efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT rosariomariapiedad efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT espinosagerard efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT demoralesjosemgarciaruiz efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT herrerasjosem efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT munozfernandezsantiago efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview AT corderocomamiguel efficacyandsafetyofimmunomodulatorydrugsinpatientswithanterioruveitisasystematicliteraturereview |