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Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis

BACKGROUND: Several previous studies were carried out on the association between xeroderma pigmentosum group G (XPG) gene polymorphisms (including rs873601 G>A, rs2094258 C>T, rs2296147 T>C, and rs751402 C>T) and the risk of gastric cancer in Chinese populations. However, their conclusio...

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Autores principales: Xia, Jun, Sun, Rulin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662374/
https://www.ncbi.nlm.nih.gov/pubmed/29049208
http://dx.doi.org/10.1097/MD.0000000000008213
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author Xia, Jun
Sun, Rulin
author_facet Xia, Jun
Sun, Rulin
author_sort Xia, Jun
collection PubMed
description BACKGROUND: Several previous studies were carried out on the association between xeroderma pigmentosum group G (XPG) gene polymorphisms (including rs873601 G>A, rs2094258 C>T, rs2296147 T>C, and rs751402 C>T) and the risk of gastric cancer in Chinese populations. However, their conclusions were not consistent. Therefore, this meta-analysis was performed by us to investigate the association between the 4 potentially functional single nucleotide polymorphisms (SNPs) of XPG gene and gastric cancer risk. METHODS: The eligible literatures were identified through PubMed, Embase, Ovid MEDLINE, Web of Science, CNKI, and Wan fang databases up to July 2017. Finally, 5 studies for rs873601, 7 studies for rs2094258, 4 studies for rs2296147, and 8 studies for rs751402 were used for the current meta-analysis. RESULTS: Of the 4 included SNPs, only rs751402 was showed to be associated with the risk of gastric cancer [C vs T, odds ratio (OR) = 1.16, 95% confidence interval (CI) = 1.04–1.29; CC + CT vs TT, OR = 1.23, 95% CI = 1.00–1.52; CC vs CT + TT, OR = 1.15, 95% CI = 1.05–1.27; CC vs TT, OR = 1.35, 95% CI = 1.06–1.72; CC vs CT, OR = 1.13, 95% CI = 1.02–1.25]. CONCLUSION: The current meta-analysis demonstrated that the XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations. However, studies with a larger number of subjects among different ethnic groups are needed to further validate the results.
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spelling pubmed-56623742017-11-21 Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis Xia, Jun Sun, Rulin Medicine (Baltimore) 5700 BACKGROUND: Several previous studies were carried out on the association between xeroderma pigmentosum group G (XPG) gene polymorphisms (including rs873601 G>A, rs2094258 C>T, rs2296147 T>C, and rs751402 C>T) and the risk of gastric cancer in Chinese populations. However, their conclusions were not consistent. Therefore, this meta-analysis was performed by us to investigate the association between the 4 potentially functional single nucleotide polymorphisms (SNPs) of XPG gene and gastric cancer risk. METHODS: The eligible literatures were identified through PubMed, Embase, Ovid MEDLINE, Web of Science, CNKI, and Wan fang databases up to July 2017. Finally, 5 studies for rs873601, 7 studies for rs2094258, 4 studies for rs2296147, and 8 studies for rs751402 were used for the current meta-analysis. RESULTS: Of the 4 included SNPs, only rs751402 was showed to be associated with the risk of gastric cancer [C vs T, odds ratio (OR) = 1.16, 95% confidence interval (CI) = 1.04–1.29; CC + CT vs TT, OR = 1.23, 95% CI = 1.00–1.52; CC vs CT + TT, OR = 1.15, 95% CI = 1.05–1.27; CC vs TT, OR = 1.35, 95% CI = 1.06–1.72; CC vs CT, OR = 1.13, 95% CI = 1.02–1.25]. CONCLUSION: The current meta-analysis demonstrated that the XPG gene polymorphism rs751402 was associated with increased susceptibility to gastric cancer in Chinese populations. However, studies with a larger number of subjects among different ethnic groups are needed to further validate the results. Wolters Kluwer Health 2017-10-20 /pmc/articles/PMC5662374/ /pubmed/29049208 http://dx.doi.org/10.1097/MD.0000000000008213 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5700
Xia, Jun
Sun, Rulin
Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title_full Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title_fullStr Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title_full_unstemmed Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title_short Association between the polymorphisms in XPG gene and gastric cancer susceptibility in Chinese populations: A PRISMA-compliant meta-analysis
title_sort association between the polymorphisms in xpg gene and gastric cancer susceptibility in chinese populations: a prisma-compliant meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662374/
https://www.ncbi.nlm.nih.gov/pubmed/29049208
http://dx.doi.org/10.1097/MD.0000000000008213
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